Mitsui Norimasa, Fukunaga Shintaro, Koura Yoshihiko, Morita Satoru, Hotei Hiroshi, Sueshiro Masafumi, Sueda Taijiro, Matsuura Yuichiro
The First Department of Surgery, Hiroshima University School of Medicine, Hiroshima, Japan.
Artif Organs. 1996 May;20(5):632-636. doi: 10.1111/j.1525-1594.1996.tb04494.x.
A computer simulation was carried out to investigate the influence of nonpulsatile left ventricular assistance on hemodynamics. A simulation circuit was constructed to represent the circulatory system. A source of current was added to denote the nonpulsatile blood pump. The left and right ventricles were replaced by variable compliances. Left heart failure was simulated by decreasing the amount of compliance change of the left ventricle. We introduced a pulsatility indicator (PI) to clarify the pulsatility characteristics in the hemodynamics; this PI was defined as the ratio of the pulse pressure (PP) to the mean aortic pressure (AoP). When nonpulsatile bypass flow increased, the mean AoP, tension time index (TTI), and diastolic pressure time index (DPTI) increased, and cardiac output, PP, and PI decreased. When assisted flow increased with the constant total flow rate, the mean AoP and DPTI changed little; the PP, TTI, and PI decreased, and the endocardial viability rate increased. The PI would be helpful in evaluating the effect of pulsatility.
进行了计算机模拟以研究非搏动性左心室辅助对血流动力学的影响。构建了一个模拟电路来代表循环系统。添加了一个电流源来表示非搏动性血泵。左右心室被可变顺应性所取代。通过减少左心室顺应性变化量来模拟左心衰竭。我们引入了一个搏动性指标（PI）来阐明血流动力学中的搏动性特征；该PI被定义为脉压（PP）与平均主动脉压（AoP）之比。当非搏动性旁路流量增加时，平均AoP、张力时间指数（TTI）和舒张压时间指数（DPTI）增加，而心输出量、PP和PI降低。当在总流量恒定的情况下辅助流量增加时，平均AoP和DPTI变化不大；PP、TTI和PI降低，而心内膜活力率增加。PI将有助于评估搏动性的效果。
