Kuo C Y, Thompson J J, Hoffmann L G
Z Immunitatsforsch Immunobiol. 1976 Sep;152(2):151-66.
The first component of guinea pig complement (C1)2) is bound in a cooperative manner to antigen-antibody complexes containing rabbit IgM antibodies, as was previously shown to be the case for IgG antibodies. The shape of the binding curves is consistent with an allosteric mechanism involving clusters of 10 interacting C1 binding sites. Similar results were obtained with IgM antibodies against an artificial hapten and against a natural constituent of the erythrocyte membrane.
豚鼠补体（C1）的第一个成分以协同方式与含有兔IgM抗体的抗原 - 抗体复合物结合，正如先前针对IgG抗体所显示的情况一样。结合曲线的形状与涉及10个相互作用的C1结合位点簇的别构机制一致。用针对人工半抗原和红细胞膜天然成分的IgM抗体也获得了类似结果。
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