秀丽隐杆线虫中的染色质沉默与功能性生殖系的维持
Chromatin silencing and the maintenance of a functional germline in Caenorhabditis elegans.
作者信息
Kelly W G, Fire A
机构信息
Department of Embryology, Carnegie Institution of Washington, Baltimore, MD 21210, USA.
出版信息
Development. 1998 Jul;125(13):2451-6. doi: 10.1242/dev.125.13.2451.
Abstract
The germline of the nematode Caenorhabditis elegans exhibits a remarkable ability to specifically silence transgenic DNA. We have shown that this silencing mechanism is disrupted in animals mutant for the maternal effect sterile genes mes-2, mes-3, mes-4 and mes-6. The proteins encoded by mes-2 and mes-6 have been shown to be related to the Polycomb Group of transcriptional repressors (Holdeman, R., Nehrt, S. and Strome, S. (1998). Development 125, 2457-2467; Korf, I., Fan, F. and Strome, S. (1998). Development 125, 2469-2478). These results suggest that a genetic silencing process is essential for sustained germline function, and that this silencing is mediated, at least in part, by Polycomb Group proteins.
摘要
秀丽隐杆线虫的种系具有特异性沉默转基因DNA的显著能力。我们已经表明，在母性效应不育基因mes-2、mes-3、mes-4和mes-6发生突变的动物中，这种沉默机制被破坏。mes-2和mes-6编码的蛋白质已被证明与转录抑制因子的多梳蛋白家族有关（霍尔德曼，R.，内尔特，S.和斯特罗姆，S.（1998年）。《发育》125卷，2457 - 2467页；科夫，I.，范，F.和斯特罗姆，S.（1998年）。《发育》125卷，2469 - 2478页）。这些结果表明，一种基因沉默过程对于种系的持续功能至关重要，并且这种沉默至少部分是由多梳蛋白家族蛋白介导的。
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MES-2, a maternal protein essential for viability of the germline in Caenorhabditis elegans, is homologous to a Drosophila Polycomb group protein.MES-2是一种对秀丽隐杆线虫生殖系存活至关重要的母体蛋白，与果蝇的一种多梳蛋白家族蛋白同源。
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The phenotype of mes-2, mes-3, mes-4 and mes-6, maternal-effect genes required for survival of the germline in Caenorhabditis elegans, is sensitive to chromosome dosage.mes-2、mes-3、mes-4和mes-6是秀丽隐杆线虫生殖系存活所需的母源效应基因，它们的表型对染色体剂量敏感。
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