Torizuka T, Zasadny K R, Recker B, Wahl R L
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109-0028, USA.
Radiology. 1998 Jun;207(3):767-74. doi: 10.1148/radiology.207.3.9609902.
To compare kinetic modeling of 2-[fluorine-18]fluoro-2-deoxy-D-glucose (F-18 FDG) between untreated primary lung and untreated primary breast cancers by using positron emission tomographic (PET) findings and to correlate these findings with findings of in vitro studies.
Nineteen patients (12 men, seven women; age range, 49-82 years) with untreated primary lung cancer and 17 women with untreated primary breast cancer (age range, 26-65 years) underwent 1-hour dynamic F-18 FDG PET. A three-compartment model was applied to F-18 FDG kinetics in tumors. The standard uptake value normalized for lean body mass (SUVlean) in tumors was measured 50-60 minutes after tracer injection. In vitro, thin-layer chromatography was performed to evaluate the intracellular phosphorylation of tritiated F-18 FDG in human lung cancer and breast cancer cell lines.
At PET, lung cancer had a significantly (P < .003) higher rate constant for F-18 FDG phosphorylation (k3) and SUVlean than did breast cancer (0.164 +/- 0.150 [standard deviation] vs 0.043 +/- 0.018 and 8.25 +/- 3.28 vs 3.17 +/- 1.08, respectively). Breast cancer showed a significant correlation between k3 and SUVlean (r = .607, P < .01), although no such correlation was observed in lung cancer. In vitro studies showed phosphorylation of F-18 FDG in breast cancer cells was less complete in hyperglycemia than it was in lung cancer cells.
A much lower k3 appears to be a rate-limiting factor for F-18 FDG accumulation in breast cancer, while the higher k3 in lung cancer is probably not rate limiting for F-18 FDG accumulation.
通过正电子发射断层扫描（PET）结果比较未经治疗的原发性肺癌和未经治疗的原发性乳腺癌中2-[氟-18]氟-2-脱氧-D-葡萄糖（F-18 FDG）的动力学模型，并将这些结果与体外研究结果相关联。
19例未经治疗的原发性肺癌患者（12例男性，7例女性；年龄范围49 - 82岁）和17例未经治疗的原发性乳腺癌女性患者（年龄范围26 - 65岁）接受了1小时的动态F-18 FDG PET检查。将三室模型应用于肿瘤中F-18 FDG的动力学研究。在示踪剂注射后50 - 60分钟测量肿瘤中瘦体重标准化的标准摄取值（SUVlean）。在体外，进行薄层色谱法评估人肺癌和乳腺癌细胞系中氚标记的F-18 FDG的细胞内磷酸化情况。
在PET检查中，肺癌的F-18 FDG磷酸化速率常数（k3）和SUVlean显著高于乳腺癌（P <.003）（分别为0.164±0.150[标准差]对0.043±0.018，以及8.25±3.28对3.17±1.08）。乳腺癌的k3与SUVlean之间存在显著相关性（r =.607，P <.01），而在肺癌中未观察到这种相关性。体外研究表明，高血糖状态下乳腺癌细胞中F-18 FDG的磷酸化不如肺癌细胞完全。
较低的k3似乎是F-18 FDG在乳腺癌中蓄积的限速因素，而肺癌中较高的k3可能不是F-18 FDG蓄积的限速因素。
