Rattay F
Technical University Vienna, Austria.
IEEE Trans Biomed Eng. 1998 Jun;45(6):766-72. doi: 10.1109/10.678611.
The artificial excitation process of neurons of the central nervous system depends on the applied extracellular field, on the geometry of the neuron and on the electrical properties of the neural subunits. Results of computer simulations are based on a compartment model of the neuron and its equivalent electrical network. Furthermore, a theory is presented which generalizes the activating function concept known from peripheral nerve stimulation. The theory predicts the influence of electrical and geometrical parameters on the excitation threshold. Generally, the myelinated axon is the part of a neuron which is most excitable to a given applied field. An example demonstrates that for a target neuron the quotient (anodic threshold current)/(cathodic threshold current) essentially depends on the position and orientation of the neuron relative to the electrode.
中枢神经系统神经元的人工激发过程取决于所施加的细胞外电场、神经元的几何形状以及神经亚基的电学特性。计算机模拟结果基于神经元的房室模型及其等效电路网络。此外，还提出了一种理论，该理论推广了从外周神经刺激中已知的激活函数概念。该理论预测了电学和几何参数对激发阈值的影响。一般来说，有髓轴突是神经元中对给定施加电场最易兴奋的部分。一个例子表明，对于目标神经元，（阳极阈值电流）/（阴极阈值电流）的商主要取决于神经元相对于电极的位置和方向。
