Yamamoto T, Katayama I, Nishioka K
Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, Japan.
J Dermatol. 1998 Apr;25(4):231-3. doi: 10.1111/j.1346-8138.1998.tb02386.x.
The nail is commonly involved in psoriasis; however, very few therapies are satisfactory. In this study, we treated for 20 cases of psoriasis vulgaris with nail involvement with topical anthralin therapy. An ointment of 0.4-2.0% anthralin in petrolatum was applied to the affected nail bed once a day and washed away with water after 30 minutes. Then, 10% triethanolamine cream was applied to prevent undesired pigmentation. Within five months of therapy, twelve out of twenty psoriatic patients (60%) showed moderate and obvious improvement, four patients (20%) showed no response to this regimen. Onycholysis and pachyonychia both responded clinically, and the number of pitting was markedly decreased in some cases. The main side effect of anthralin therapy was reversible pigmentation of the nail plate. Topical anthralin therapy is effective for nail psoriasis and considered to be a useful treatment for refractory nail psoriasis.
指甲常受累于银屑病；然而，令人满意的治疗方法却很少。在本研究中，我们采用外用蒽林疗法治疗了20例伴有指甲受累的寻常型银屑病患者。将含0.4 - 2.0%蒽林的凡士林软膏每天一次涂抹于受累甲床，30分钟后用水冲洗掉。然后，涂抹10%三乙醇胺乳膏以防止出现不期望的色素沉着。在治疗的五个月内，20例银屑病患者中有12例（60%）显示出中度至明显改善，4例患者（20%）对该治疗方案无反应。甲剥离和甲肥厚在临床上均有反应，并且在某些病例中凹点数量明显减少。蒽林疗法的主要副作用是甲板可逆性色素沉着。外用蒽林疗法对指甲银屑病有效，被认为是治疗难治性指甲银屑病的一种有用方法。
