Zakeri Mehrnaz, Valikhani Mahin, Mortazavi Hossein, Barzegari Masoomeh
Department of Dermatology, Razi Dermatology Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Dermatol Online J. 2005 Dec 1;11(3):5.
There are few reports regarding the treatment of nail psoriasis with topical calcipotriol. We undertook a case series study to evaluate the efficacy and safety of calcipotriol ointment (50 microg/g) in the treatment of nail psoriasis in 24 patients. This study involved 19 women and 5 men with nail psoriasis referred to Dermatology clinics of Razi hospital. The duration of trial was from October 2002 to September 2004. Informed consent was obtained from all patients before entering into the study. The patients applied calcipotriol ointment to the affected nails twice daily without occlusion for 3 months. Patients were seen by two academic dermatologists initially, after 2 weeks, and then at monthly intervals. The efficacy and safety were clinically assessed and any side effect was recorded. Patients who showed 50 percent or greater reduction in the baseline subungual thickness in at least one nail were considered to be responders and were offered continuation of therapy for an additional 2 months. After discontinuation of therapy, followup visits were performed at 1 and 2 months. After 3 months of therapy, fourteen patients showed significant clinical improvement, two of them were completely free from nail lesions after 5 months. Calcipotriol was particularly effective in subungual hyperkeratosis, onycholysis, and discoloration. In four patients fingertip tenderness and in one case the pain of involved distal phalanx were significantly reduced. No clinical response was observed in four patients. Only two cases showed adverse reactions. Topical Calcipotriol is an effective treatment for nail psoriasis and can be considered to be a safe topical treatment in chronic cases; its high tolerability allows prolonged usage without severe side effects.
关于外用卡泊三醇治疗甲银屑病的报道较少。我们进行了一项病例系列研究，以评估卡泊三醇软膏（50μg/g）治疗24例甲银屑病患者的疗效和安全性。本研究纳入了19名女性和5名男性甲银屑病患者，他们均转诊至拉齐医院皮肤科门诊。试验时间为2002年10月至2004年9月。所有患者在进入研究前均签署了知情同意书。患者每天两次将卡泊三醇软膏涂抹于受累指甲，不封包，持续3个月。最初由两名皮肤科专科医生对患者进行检查，2周后检查，随后每月检查一次。对疗效和安全性进行临床评估，并记录任何副作用。至少一个指甲的基线甲下厚度减少50%或更多的患者被视为有反应者，并继续接受治疗2个月。停止治疗后，在1个月和2个月时进行随访。治疗3个月后，14名患者有显著的临床改善，其中2名患者在5个月后指甲病变完全消失。卡泊三醇对角化过度、甲分离和变色特别有效。4名患者的指尖压痛和1例受累远端指骨疼痛明显减轻。4名患者未观察到临床反应。仅2例出现不良反应。外用卡泊三醇是治疗甲银屑病的有效方法，在慢性病例中可被视为一种安全的局部治疗方法；其高耐受性允许长期使用而无严重副作用。
