印度非麻风病患者中酚糖脂IgG抗体的高发生率。
High incidence of IgG antibodies to phenolic glycolipid in non-leprosy patients in India.
作者信息
Kumar B, Sinha R, Sehgal S
机构信息
Department of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
出版信息
J Dermatol. 1998 Apr;25(4):238-41. doi: 10.1111/j.1346-8138.1998.tb02388.x.
Purified phenolic glycolipid (PGL-1) from Mycobacterium leprae was used to detect IgG antibodies against PGL-1 in leprosy patients in an enzyme-linked immunosorbent assay (ELISA). A total of 698 sera were screened; they came from patients suffering from leprosy, autoimmune disease, myeloma, tuberculosis and sexually transmitted diseases (STDs). Cases with miscellaneous diseases and persons undergoing AIDS screening were also included. Sera from lepromatous and tuberculoid leprosy patients gave positivity rates of 60.5% and 41.7%, respectively. In non-leprosy cases, the PGL-1 ELISA showed an overall positivity rate of 6.9%; this was greatest in patients with tuberculosis (43.8%) followed by autoimmune diseases (40.9%) and miscellaneous cases including liver diseases (37.9%). This study emphasizes that PGL-1 ELISA has a low predictive value for diagnosis of active infection by Mycobacterium leprae. Positive reactions in a significant percentage of patients with autoimmune disease are intriguing and need indepth study.
从麻风分枝杆菌中提纯的酚糖脂（PGL-1）用于酶联免疫吸附测定（ELISA），检测麻风病人血清中抗PGL-1的IgG抗体。共检测了698份血清样本，这些样本来自麻风病人、自身免疫性疾病患者、骨髓瘤患者、结核病患者及性传播疾病（STD）患者。还纳入了患有其他杂病的病例及接受艾滋病筛查的人员。瘤型麻风患者和结核样型麻风患者血清的阳性率分别为60.5%和41.7%。在非麻风病病例中，PGL-1 ELISA总体阳性率为6.9%；其中结核病患者阳性率最高（43.8%），其次是自身免疫性疾病患者（40.9%）和包括肝病在内的其他杂病患者（37.9%）。本研究强调，PGL-1 ELISA对麻风分枝杆菌活动性感染诊断的预测价值较低。相当比例的自身免疫性疾病患者出现阳性反应，这一现象值得关注且需要深入研究。
Zotero 插件