Postmortem diagnosis of accidental cocaine intoxication in a dog.

Despite an abundance of data on the experimental effects of cocaine in dogs, no detailed reports documenting accidental cocaine exposure in domestic pets have been reported in the veterinary literature. A case of cocaine intoxication is described in a 19-mo-old male catahoula hound in which the diagnosis was confirmed using histopathology, thin-layer chromatography and mass spectrometry. The case was presented as a possible intoxication of unknown etiology. Routine toxicologic screens and characteristic histologic lesions provided evidence for the diagnosis without prior suspicion of cocaine involvement.