Madden J J, Whaley W L, Ketelsen D
Department of Psychiatry and Behavioral Science, Emory University School of Medicine, Atlanta, GA 30322, USA.
J Neuroimmunol. 1998 Mar 15;83(1-2):57-62. doi: 10.1016/s0165-5728(97)00221-x.
The direct actions of opiates on the mammalian immune system depend on the existence of ligand binding sites either on the surface of the affected cell or in the interior of the cell. With the cloning of various opiate receptors from neuronal tissue, numerous researchers have screened leukocyte cDNA libraries for the expression of these receptors with some positive results. However, the pattern of expression of neuronal opiate receptors in the cellular immune system does not completely explain the biological action of opiates there. Several possibilities could account for this non-congruence including differential expression of the receptors as determined by such factors as cell population or prior history of the cells; the existence of sequence modified versions of the neuronal receptors such that the amplification methods miss their presence; or the opiates act by a different, non-receptor mechanism in the cellular immune system.
阿片类药物对哺乳动物免疫系统的直接作用取决于在受影响细胞表面或细胞内部是否存在配体结合位点。随着从神经元组织中克隆出各种阿片受体，众多研究人员筛查了白细胞cDNA文库中这些受体的表达情况，取得了一些阳性结果。然而，神经元阿片受体在细胞免疫系统中的表达模式并不能完全解释阿片类药物在该系统中的生物学作用。有几种可能性可以解释这种不一致性，包括受体的差异表达，这取决于细胞群体或细胞既往史等因素；存在神经元受体的序列修饰版本，以至于扩增方法未能检测到它们的存在；或者阿片类药物在细胞免疫系统中通过不同的非受体机制发挥作用。
