内源性非肽类吗啡样化合物与阿片受体的结合。
Binding of the endogenous nonpeptide morphine-like compound to opiate receptors.
作者信息
Blume A J, Shorr J, Finberg J P, Spector S
出版信息
Proc Natl Acad Sci U S A. 1977 Nov;74(11):4927-31. doi: 10.1073/pnas.74.11.4927.
Abstract
The endogenous central nervous tissue substance called MLC (morphine-like compound) is shown to bind to the opiate receptors of the mouse neuroblastoma X glioma hybrid cell line NG108-15. The interaction of MLC with these opiate receptors is noncooperative, as is the interaction of morphine, naloxone, and Leu-enkephalin with these receptors. A specific antibody to morphine will bind MLC but will not bind beta-endorphin, Leu-enkephalin, or Met-enkephalin. It would appear, therefore, that MLC can be considered to be a different type of endogenous ligand for the opiate receptor.
摘要
一种名为MLC（吗啡样化合物）的内源性中枢神经组织物质，已被证明能与小鼠神经母细胞瘤X胶质瘤杂交细胞系NG108 - 15的阿片受体结合。MLC与这些阿片受体的相互作用是非协同性的，吗啡、纳洛酮和亮氨酸脑啡肽与这些受体的相互作用也是如此。一种针对吗啡的特异性抗体能结合MLC，但不能结合β - 内啡肽、亮氨酸脑啡肽或甲硫氨酸脑啡肽。因此，似乎可以认为MLC是阿片受体的一种不同类型的内源性配体。
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A SENSITIVE FLUOROMETRIC ASSAY FOR MORPHINE IN PLASMA AND BRAIN.一种用于检测血浆和大脑中吗啡的灵敏荧光测定法。
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