Blume A J, Shorr J, Finberg J P, Spector S
Proc Natl Acad Sci U S A. 1977 Nov;74(11):4927-31. doi: 10.1073/pnas.74.11.4927.
The endogenous central nervous tissue substance called MLC (morphine-like compound) is shown to bind to the opiate receptors of the mouse neuroblastoma X glioma hybrid cell line NG108-15. The interaction of MLC with these opiate receptors is noncooperative, as is the interaction of morphine, naloxone, and Leu-enkephalin with these receptors. A specific antibody to morphine will bind MLC but will not bind beta-endorphin, Leu-enkephalin, or Met-enkephalin. It would appear, therefore, that MLC can be considered to be a different type of endogenous ligand for the opiate receptor.
一种名为MLC(吗啡样化合物)的内源性中枢神经组织物质,已被证明能与小鼠神经母细胞瘤X胶质瘤杂交细胞系NG108 - 15的阿片受体结合。MLC与这些阿片受体的相互作用是非协同性的,吗啡、纳洛酮和亮氨酸脑啡肽与这些受体的相互作用也是如此。一种针对吗啡的特异性抗体能结合MLC,但不能结合β - 内啡肽、亮氨酸脑啡肽或甲硫氨酸脑啡肽。因此,似乎可以认为MLC是阿片受体的一种不同类型的内源性配体。