Sopori M L, Kozak W
Pathophysiology Division, Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA.
J Neuroimmunol. 1998 Mar 15;83(1-2):148-56. doi: 10.1016/s0165-5728(97)00231-2.
Cigarette smoke is a major health risk factor which significantly increases the incidence of diseases including lung cancer and respiratory infections. This increased susceptibility may result from cigarette smoke-induced impairment of the immune system. While the acute effects of cigarette smoke on the immune system are less clear, chronic exposure to cigarette smoke or nicotine causes T cell unresponsiveness. This apparent T cell anergy may account for or contribute to the immunosuppressive and anti-inflammatory properties of cigarette smoke/nicotine. Nicotine-induced immunosuppression may result from its direct effects on lymphocytes, indirectly through its effects on the neuroendocrine system, or both.
香烟烟雾是一个主要的健康风险因素，它会显著增加包括肺癌和呼吸道感染在内的疾病发病率。这种易感性增加可能是由于香烟烟雾引起的免疫系统损伤所致。虽然香烟烟雾对免疫系统的急性影响尚不清楚，但长期接触香烟烟雾或尼古丁会导致T细胞无反应性。这种明显的T细胞无反应性可能解释或促成了香烟烟雾/尼古丁的免疫抑制和抗炎特性。尼古丁诱导的免疫抑制可能是由于其对淋巴细胞的直接作用、通过对神经内分泌系统的作用间接导致的，或者是两者共同作用的结果。
