Piao Wen-Hua, Campagnolo Denise, Dayao Carlos, Lukas Ronald J, Wu Jie, Shi Fu-Dong
Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA.
Acta Pharmacol Sin. 2009 Jun;30(6):715-22. doi: 10.1038/aps.2009.67. Epub 2009 May 18.
Cigarette smoke is a major health risk factor which significantly increases the incidence of diseases including lung cancer and respiratory infections. However, there is increasing evidence that smokers have a lower incidence of some inflammatory and neurodegenerative diseases. Nicotine is the main immunosuppressive constituent of cigarette smoke, which inhibits both the innate and adaptive immune responses. Unlike cigarette smoke, nicotine is not yet considered to be a carcinogen and may, in fact, have therapeutic potential as a neuroprotective and anti-inflammatory agent. This review provides a synopsis summarizing the effects of nicotine on the immune system and its (nicotine) influences on various neurological diseases.
香烟烟雾是一个主要的健康风险因素，它会显著增加包括肺癌和呼吸道感染在内的疾病发病率。然而，越来越多的证据表明，吸烟者患某些炎症性和神经退行性疾病的发病率较低。尼古丁是香烟烟雾中的主要免疫抑制成分，它会抑制先天性和适应性免疫反应。与香烟烟雾不同，尼古丁尚未被视为致癌物，事实上，它可能具有作为神经保护剂和抗炎剂的治疗潜力。这篇综述提供了一个概要，总结了尼古丁对免疫系统的影响及其（尼古丁）对各种神经系统疾病的影响。
