García M T, Juncosa T, Jordán Y, González A, Coll P, Latorre C
Servicio de Pediatría, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona.
Enferm Infecc Microbiol Clin. 1998 Mar;16(3):132-4.
To study the factors implicated in the infectious process (host, microorganism and antibiotic) of a newborn early sepsis by S. agalactiae that suffered a reactivation at day five from discharge.
Description of two episodes of newborn sepsis by S. agalactiae corresponding to the same patient and microbiologic study of the isolated strain: typing by "genomic macrorestriction" and antibiotic tolerance by "timed killing curves".
It was demonstrated that both strains of S. agalactiae type la/c belonged to the same clone as well as the tolerance to ampicillin of the strain.
This sort of infections processes in the newborn are very serious and there is possibility of relapse. Thus, it is important to study the ethiologic agent and its relationship with antibiotics, in order to stablish the best treatment regimes, avoiding the possibility of relapses as the case we have described.
研究一名出生时感染无乳链球菌早期败血症的新生儿在出院后第五天病情复发时涉及感染过程的因素（宿主、微生物和抗生素）。
描述同一患者的两例无乳链球菌新生儿败血症发作情况，并对分离菌株进行微生物学研究：通过“基因组酶切图谱”分型，通过“定时杀菌曲线”检测抗生素耐受性。
证实两株la/c型无乳链球菌属于同一克隆，且该菌株对氨苄西林具有耐受性。
新生儿中的这类感染过程非常严重，且有复发的可能性。因此，研究病原体及其与抗生素的关系很重要，以便建立最佳治疗方案，避免像我们所描述的病例那样出现复发的可能性。
