Kashiwabara K, Nakamura H, Kishi K, Kiguchi T, Yagyu H, Kobayashi K, Matsuoka T
5th Department of Internal Medicine, Tokyo Medical College, Ibaraki, Japan.
Nihon Kokyuki Gakkai Zasshi. 1998 Jan;36(1):29-33.
We evaluated the relationship of carcinoembryonic antigen (CEA) and neutrophils to pulmonary function in healthy smokers. Smokers in whom levels of CEA were greater than 5.0 ng/ml (n = 70) and in whom CEA levels were 5.0 ng/ml or less (n = 693) had significantly higher mean concentrations of leukocytes and neutrophils than non-smokers (n = 651) (leukocytes: 6,883 +/- 1,889/mm3 or 5,581 +/- 1,457/mm3 vs. 4,507 +/- 1,111/mm3, p < 0.01; neutrophils: 4,389 +/- 1,542/mm3 or 3,343 +/- 1,164/mm3 vs. 2,700 +/- 884/mm3, p < 0.01). Differences in the ratio of vital capacity to the predicted vital capacity (%VC) were not significant. In addition, the ratio of forced expiratory volume in one second to forced vital capacity (FEV 1.0%) in smokers with CEA levels greater than 5.0 ng/ml was decreased compared with smokers with CEA levels of 5.0 ng/ml or less and in non-smokers (90.2 +/- 8.4% vs. 93.3 +/- 6.7% or 92.9 +/- 6.5%, p < 0.01). These results suggest that in healthy smokers high serum CEA levels are related to a decreased FEV 1.0%.
我们评估了癌胚抗原（CEA）和中性粒细胞与健康吸烟者肺功能之间的关系。CEA水平大于5.0 ng/ml的吸烟者（n = 70）和CEA水平为5.0 ng/ml或更低的吸烟者（n = 693），其白细胞和中性粒细胞的平均浓度显著高于非吸烟者（n = 651）（白细胞：6,883 ± 1,889/mm³或5,581 ± 1,457/mm³ vs. 4,507 ± 1,111/mm³，p < 0.01；中性粒细胞：4,389 ± 1,542/mm³或3,343 ± 1,164/mm³ vs. 2,700 ± 884/mm³，p < 0.01）。肺活量与预测肺活量的比值（%VC）差异不显著。此外，CEA水平大于5.0 ng/ml的吸烟者一秒用力呼气量与用力肺活量的比值（FEV 1.0%）与CEA水平为5.0 ng/ml或更低的吸烟者以及非吸烟者相比有所降低（90.2 ± 8.4% vs. 93.3 ± 6.7%或92.9 ± 6.5%，p < 0.01）。这些结果表明，在健康吸烟者中，高血清CEA水平与FEV 1.0%降低有关。
