Knispel J, Wilken H
Zentralbl Gynakol. 1976;98(8):449-54.
The ratio of estrogen excretion in urine (milligrams per 24 h) divided by creatinine (grams per 24 h) was determined in 571 specimens of 307 pregnant women and compared with total estrogen determinations. Use of estrogen-creatinine ratio reduced the daily variations of total estrogen values by one third resulting in a mean curve with less standard deviation.
对307名孕妇的571份尿液样本测定了尿中雌激素排泄量(毫克/24小时)与肌酐(克/24小时)的比值,并与总雌激素测定结果进行比较。使用雌激素-肌酐比值可使总雌激素值的每日变化减少三分之一,从而得到一条标准差较小的平均曲线。