Kovalenko V L, Kurenkov E L, Koksharov V N
State Medical Academy, Chelyabinsk.
Arkh Patol. 1998 Mar-Apr;60(2):18-23.
A morphological study of biopsy samples of gastric polyps from 224 patients was carried out. Four stages in gastric polyp morphogenesis were distinguished: foveolar hyperplasia, hyperplastic polyp, "two-floor" adenoma and adenoma. The correlation was established between the degree of Helicobacter pylori infection in the polyp mucous membrane on the one hand, and epithelial and stromal reactions (immuno-inflammatory reaction of stroma, chronic inflammation, formation of Russel bodies, cystes and chronic erosions) on the other. Greater content of stromal collagens, type IV collagen in case of gastric hyperplastic lesions was observed. Appearance and progression of gastric adenomatous growth in hyperplastic polyp correlates with an increase of type III collagen content, decrease of types I, IV, V collagens and fibronectin.
对224例患者的胃息肉活检样本进行了形态学研究。区分了胃息肉形态发生的四个阶段：小凹增生、增生性息肉、“双层”腺瘤和腺瘤。一方面，息肉黏膜中幽门螺杆菌感染程度与另一方面的上皮和基质反应（基质的免疫炎症反应、慢性炎症、Russel小体形成、囊肿和慢性糜烂）之间建立了相关性。观察到在胃增生性病变中基质胶原蛋白、IV型胶原蛋白含量更高。增生性息肉中胃腺瘤性生长的出现和进展与III型胶原蛋白含量增加、I型、IV型、V型胶原蛋白和纤连蛋白含量降低相关。
