Filipenko M L, Vinichenko N A, Karpova G G, Mertvetsov N P, Amaldi F
Novosibirsk Institute of Bioorganic Chemistry, Russian Academy of Sciences, Russia.
Genetika. 1998 Apr;34(4):469-74.
Gene HRPS26 encoding the S26 human ribosomal protein has been sequenced. Gene HRPS26 consists of four exons and three introns. Its size is 2027 bp; the size of its mRNA is 438 nucleotides. As most of the genes of ribosomal proteins of vertebrates, the HRPS26 gene has a short first exon, which corresponds to the 5'-untranslated region of mRNA; the origin of transcription is located in the polypyrimidine tract. The functional activity of the cloned HRPS26 promoter region has been confirmed by transcription of hybrid plasmids in HeLa cells.
编码人核糖体蛋白S26的基因HRPS26已被测序。基因HRPS26由四个外显子和三个内含子组成。其大小为2027碱基对；其mRNA大小为438个核苷酸。与大多数脊椎动物核糖体蛋白基因一样，HRPS26基因的第一个外显子很短，它对应于mRNA的5'非翻译区；转录起始位点位于多嘧啶序列中。通过在HeLa细胞中对杂交质粒进行转录，已证实克隆的HRPS26启动子区域的功能活性。
