Müller P, Engelstädter M, Werner A, Braner J, Staszewski S, Miller V, Doerr H W, Kurth R, Cichutek K
Department of Medical Biotechnology, Paul-Ehrlich-Institut, Langen, Germany.
Intervirology. 1997;40(4):263-70. doi: 10.1159/000150556.
The serum levels of the beta-chemokine RANTES and, albeit less, MIP-1 beta were found to be increased in 37 HIV-1 infected compared to seronegative individuals. In contrast the serum levels of IL-16 were only sporadically elevated in seropositives as well as in seronegatives. Concomitantly, the RANTES gene expression increased about tenfold in seropositives, whereas the MIP-1 beta and IL-16 mRNA levels were not elevated. No correlation between the increase of the MIP-1 beta and RANTES serum concentrations and the plasma virus load, the number of the peripheral CD4+ T cells or the therapy status of the patients was found. However, the increased proportion of activated CD8+CD38+ T cells in the peripheral blood of all seropositives paralleled the increased RANTES serum levels detected indicating that immune activation in HIV-1-infected individuals may contribute to increased RANTES serum levels.
与血清阴性个体相比，在37名HIV-1感染者中发现β趋化因子RANTES以及程度稍轻的MIP-1β的血清水平升高。相比之下，IL-16的血清水平在血清阳性者以及血清阴性者中仅偶尔升高。同时，RANTES基因表达在血清阳性者中增加了约10倍，而MIP-1β和IL-16的mRNA水平并未升高。未发现MIP-1β和RANTES血清浓度的升高与血浆病毒载量、外周血CD4+T细胞数量或患者的治疗状态之间存在相关性。然而，所有血清阳性者外周血中活化的CD8+CD38+T细胞比例增加与检测到的RANTES血清水平升高平行，表明HIV-1感染者的免疫激活可能导致RANTES血清水平升高。
