Chambon R, Lemardeley P, Boudin C, Ringwald P, Chandenier J
Observatoire Régional de la Santé, Organisation de Coordination pour la Lutte contre les Endémies en Afrique centrale, Yaoundé, Cameroun.
Med Trop (Mars). 1997;57(4):357-60.
The Malaria Control Division of the Organization for Endemic Disease Control in Central Africa (OCEAC) has developed a standardized method to measure the in vivo sensitivity of Plasmodium falciparum to antimalarial drugs. Between May 1996 and February 1997, a first series of tests using this method was carried out to determine the sensitivity of Plasmodium falciparum to chloroquine and amodiaquine in infected school children in four capital cities: Yaoundé, Brazzaville, Malabo, and Libreville. As expected, only children presenting more than 100 parasites per 1000 leucocytes were enrolled. Results showed variable degrees of in vivo resistance to chloroquine and amodiaquine at each location: 25% and 13% respectively in Yaoundé, 19% and 11% in Malabo, 23% and 43% in Brazzaville, and 29% and 0% in Libreville. Overall results concerning chloroquine of this test series were similar to recent data in comparable populations and confirmed the idea that the situation has stabilized in Central Africa. Findings concerning amodiaquine raise the need for further study to validate and explain the contrasting findings in Libreville (0%) and Brazzaville (43%). This first experience shows that the method is simple and quick and that it can be used with minimal means. Results could provide important early warning data for national health officials.
中非地方病控制组织（OCEAC）的疟疾控制司已开发出一种标准化方法，用于测量恶性疟原虫对抗疟药物的体内敏感性。1996年5月至1997年2月期间，首次使用该方法进行了一系列测试，以确定雅温得、布拉柴维尔、马拉博和利伯维尔这四个首都城市感染疟原虫的学童中恶性疟原虫对氯喹和氨酚喹的敏感性。不出所料，只有每千个白细胞中疟原虫超过100个的儿童被纳入研究。结果显示，每个地点对氯喹和氨酚喹的体内耐药程度各不相同：雅温得分别为25%和13%，马拉博为19%和11%，布拉柴维尔为23%和43%，利伯维尔为29%和0%。该测试系列中关于氯喹的总体结果与可比人群中的近期数据相似，并证实了中非的情况已趋于稳定这一观点。关于氨酚喹的研究结果表明，需要进一步研究以验证和解释利伯维尔（0%）和布拉柴维尔（43%）的对比结果。这首次经验表明该方法简单快捷，且使用成本极低。研究结果可为国家卫生官员提供重要的早期预警数据。
