Shefer V F
Zh Nevropatol Psikhiatr Im S S Korsakova. 1976;76(7):1032-6.
In the light of comtemporary concepts concerning the functional significance of the limbic system, the author reports of some results in the subiculum in young and old individuals (39 cases) with different forms of dementia of old age (senile and vascular dementia, Pick's and Alzheimer's disease). The authors assessed the thickness of the subicular cortical stratum, the relative and absolute amount of nervous and glial cells and capillaries. In old age the thickness of the subicular cortical stratum is decreased by 28%, while the absolute amount of neurons by 29%. In old age dementia the thickness of the subicular cortical stratum decreased by 47--71% and the absolute amount of neurons becomes 2--3 times less. In old age in general and in dementia of old age in particular there was no "substitutional" gliosis because the absolute amount of glial cells in the cortical stratum is reduced in this group of individuals by 20--50%.
根据当代关于边缘系统功能意义的概念，作者报告了对39例患有不同形式老年痴呆症（老年性和血管性痴呆、匹克氏病和阿尔茨海默病）的年轻人和老年人海马下托的一些研究结果。作者评估了海马下托皮质层的厚度、神经细胞、神经胶质细胞和毛细血管的相对数量和绝对数量。老年人海马下托皮质层的厚度减少了28%，而神经元的绝对数量减少了29%。在老年痴呆症患者中，海马下托皮质层的厚度减少了47%-71%，神经元的绝对数量减少为原来的二至三分之一。总体而言，在老年人中，特别是在老年痴呆症患者中，不存在“替代性”胶质增生，因为这组个体皮质层中神经胶质细胞的绝对数量减少了20%-50%。
