[Cholestasis assessment by activity of antioxidant enzymes and composition of plasma lipoproteins in patients with liver diseases].

AIM

Investigation of activity of copper-containing enzymes in plasma superoxide dismutase (SOD) and ceruloplasmin (CP) in comparison with concentrations of lipoproteins (LP) of the main classes in patients with chronic hepatic diseases (CHD).

MATERIALS AND METHODS

SOD activity, CP and LP in plasma were measured in 90 patients with CHD.

RESULTS

An inverse relationship was found between SOD activity and CP content in CHD. SOD/CP ratio proved informative in cholestasis assessment. An increased ratio beta-LP/alpha-LP was noticed in patients with primary biliary cirrhosis. This value and the disease severity correlated.

CONCLUSION

Patients with cholestatic hepatic lesions exhibited inhibition of enzyme utilization of superoxide radicals in plasma in line with enhancement of CP secretion.