[急性酒精性精神病中的硫胺缺乏症]

[Thiamine deficit in acute alcoholic psychoses].

作者信息

Mileĭkovskiĭ Iu A

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1976;76(7):1074-9.

Abstract

In 35 females and 22 males with acute alcoholic disorders and in 44 individuals of a control group the author studied the indices of thiamine balance--the content of thiamine and pyruvic acid in the blood and urine, concentration of citric acid in the blood, activity of transketolase of erythrocytes and TDP-effect. The results demonstrated that a thiamide deficiency in excretion and insufficiency in coenzyme functions of oxidative decarboxylation of pyruvic acid and in the pentose cycle is seen not only in alcoholic psychoses, but in the withdrawal syndrome. Sex differences of these indices and their development were not noted. It is assumed that the clinical traits of alcoholic disorders in females are not related to changes in the thiamine metabolism.

摘要

作者对35名患有急性酒精性疾病的女性、22名患有急性酒精性疾病的男性以及44名对照组个体的硫胺素平衡指标进行了研究，这些指标包括血液和尿液中硫胺素及丙酮酸的含量、血液中柠檬酸的浓度、红细胞转酮醇酶的活性以及TDP效应。结果表明，不仅在酒精性精神病患者中，而且在戒断综合征患者中，均存在硫胺素排泄缺乏以及丙酮酸氧化脱羧辅酶功能和戊糖循环不足的情况。未观察到这些指标及其发展的性别差异。据推测，女性酒精性疾病的临床特征与硫胺素代谢变化无关。