Takubo K, Nakamura K, Arai T, Nakachi K, Ebuchi M
Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology.
Nihon Rinsho. 1998 May;56(5):1283-6.
In order to clarify the relationship between the telomeric length of human female breast carcinoma cells and patient age, and between telomeric length and the histological type of carcinoma, we examined 64 patients (aged 20-89 years) with breast carcinoma by histological and southern blot analysis. No difference in the telomeric length was recognizable among the three major histological types: papillotubular, solid tubular and scirrhous (7.9-8.7 kilobase pairs (kbp)). Mean telomere lengths in the groups aged under 35 (8 patients), 36-50 (10 patients), 51-70 (17 patients), 71-80 (19 patients), and over 81 years (10 patients) were 11.0, 9.9, 7.0, 7.7 and 7.6 kbp, respectively. There was no significant evidence for telomeric shortening in breast carcinoma according to patient age. Two peaks of telomeric length were observed in three carcinomas comprising a medullary carcinoma and two solid tubular carcinomas showing very prominent lymphocyte infiltration histologically.
为了阐明人类女性乳腺癌细胞的端粒长度与患者年龄之间的关系，以及端粒长度与癌组织学类型之间的关系，我们通过组织学和Southern印迹分析检查了64例年龄在20至89岁之间的乳腺癌患者。在三种主要组织学类型（乳头管状、实体管状和硬癌）之间，端粒长度没有明显差异（7.9 - 8.7千碱基对（kbp））。年龄在35岁以下（8例）、36 - 50岁（10例）、51 - 70岁（17例）、71 - 80岁（19例）和81岁以上（10例）的组中端粒平均长度分别为11.0、9.9、7.0、7.7和7.6 kbp。没有明显证据表明乳腺癌的端粒长度会根据患者年龄而缩短。在三例癌中观察到两个端粒长度峰值，其中包括一例髓样癌和两例实体管状癌，这两例实体管状癌在组织学上显示出非常明显的淋巴细胞浸润。
