Ylitalo P, Saarnivaara L, Ahtee L
Acta Anaesthesiol Scand. 1976;20(3):216-220. doi: 10.1111/j.1399-6576.1976.tb05032.x.
The effects of ketamine anaesthesia (100 mg/kg i.p.) on the content of brain 5-hydroxytryptamine (5HT), 5-hydroxyindoleacetic acid (5HIAA), noradrenaline (NA), dopamine (DA) and homovanillic acid (HVA) were studied in male Wistar rats. Fifteen min after ketamine injection, when the rats were deeply anaesthetized, the 5HT content in many brain regions tended to be increased. An opposite tendency was found in the brain 5HIAA content. In rats treated with probenecid, which markedly lengthened ketamine anaesthesia, the accumulation of 5HIAA was significantly reduced by ketamine. In addition to ketamine anaesthesia, probenecid was found to lengthen thiopental anaesthesia. One hour after the ketamine administration, when the rats were no longer anaesthetized but were excited, the brain NA concentration was increased by 17% (P less than 0.02). The brain DA content was unchanged, but at 15 min and 1 hour after ketamine administration the striatal HVA content was increased by about 55% (P less than 0.05), suggesting an increased turnover of DA. The results suggest that during recovery from ketamine anaesthesia the increased NA content and the increased DA turnover may be associated with the postanaesthetic excitement of the rat, whereas the decreasamine anaesthesia.
研究了氯胺酮麻醉（腹腔注射100mg/kg）对雄性Wistar大鼠脑内5-羟色胺（5HT）、5-羟吲哚乙酸（5HIAA）、去甲肾上腺素（NA）、多巴胺（DA）和高香草酸（HVA）含量的影响。注射氯胺酮15分钟后，大鼠深度麻醉时，许多脑区的5HT含量有升高趋势。脑内5HIAA含量则呈现相反趋势。在用丙磺舒处理的大鼠中，丙磺舒显著延长了氯胺酮麻醉时间，氯胺酮使5HIAA的蓄积明显减少。除氯胺酮麻醉外，还发现丙磺舒可延长硫喷妥钠麻醉时间。给予氯胺酮1小时后，大鼠不再麻醉而是处于兴奋状态时，脑内NA浓度升高了17%（P<0.02）。脑内DA含量未变，但在给予氯胺酮后15分钟和1小时，纹状体HVA含量升高了约55%（P<0.05），提示DA周转增加。结果表明，在氯胺酮麻醉苏醒过程中，NA含量增加和DA周转增加可能与大鼠麻醉后兴奋有关，而……胺麻醉降低。（原文此处“decreasamine anaesthesia”表述有误，可能影响整体理解）
