绵羊皮肤鳞状细胞癌：相关炎症浸润中CD3、CD4、CD8和MHC II类抗原的免疫组化表达

Ovine cutaneous squamous cell carcinoma: immunohistochemical expression of CD3, CD4, CD8 and MHC class II antigens in the associated inflammatory infiltrate.

作者信息

Mozos E, Méndez A, Martín M P, Herráez P, Pérez J

机构信息

Department of Comparative Pathology, Veterinary Faculty, University of Córdoba, Spain.

出版信息

Vet Immunol Immunopathol. 1998 Feb 27;61(2-4):221-8. doi: 10.1016/s0165-2427(97)00131-1.

DOI:10.1016/s0165-2427(97)00131-1

PMID:9613436

Abstract

The immunohistochemical expression of CD3, CD4, CD8 and MHC class II antigens in the cellular inflammatory infiltrate associated with early and advanced ovine squamous cell carcinomas (OSCC), as well as actinic keratosis was analyzed. The majority of the peritumoral and intratumoral lymphocytes reacted with the anti-human CD3 polyclonal antibody. The number of CD8+ T lymphocytes increased in advanced OSCC compared with that of actinic keratosis and early OSCC, whereas the number of CD4+ lymphocytes was similar in early and advanced OSCC. Tumor cells were unreactive with the anti-MHC class II antibody, but the majority of the mononuclear cellular infiltrate expressed this antigen in early and advanced tumors.

摘要

分析了与早期和晚期绵羊鳞状细胞癌（OSCC）以及光化性角化病相关的细胞炎性浸润中CD3、CD4、CD8和MHC II类抗原的免疫组化表达。大多数肿瘤周围和肿瘤内淋巴细胞与抗人CD3多克隆抗体发生反应。与光化性角化病和早期OSCC相比，晚期OSCC中CD8 + T淋巴细胞数量增加，而早期和晚期OSCC中CD4 +淋巴细胞数量相似。肿瘤细胞与抗MHC II类抗体无反应，但大多数单核细胞浸润在早期和晚期肿瘤中表达该抗原。