Curtis A, Wilkinson C
Centre for Cell Engineering, University of Glasgow, UK.
Biomaterials. 1997 Dec;18(24):1573-83. doi: 10.1016/s0142-9612(97)00144-0.
We review the literature on the reaction of cells to their surrounding topography. The topography may be that of surrounding cells, intercellular materials or biomaterials. The reactions include cell orientation, rates of movement, and activations of the cells. We concentrate on those papers where quantitative measurements of the reactions have been made and largely ignore those on subjective impressions. A wide range of topographies are considered but special attention is given to results on groove-ridge topographies. The question of whether the cells are reacting to the topography directly or to patterned substratum chemistry formed on the topography is discussed. The review ends with a summary of the types of prosthesis where advantage has been taken of the ability to fabricate topography.
我们回顾了有关细胞对其周围形貌反应的文献。这种形貌可能是周围细胞、细胞间物质或生物材料的形貌。这些反应包括细胞取向、移动速率和细胞激活。我们专注于那些对反应进行了定量测量的论文，而在很大程度上忽略了那些关于主观印象的论文。我们考虑了广泛的形貌，但特别关注了沟槽 - 脊状形貌的研究结果。文中讨论了细胞是直接对形貌做出反应，还是对在形貌上形成的图案化基质化学做出反应这一问题。综述最后总结了利用制造形貌能力的假体类型。
