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戒酒委员会登记原因的多变量遗传分析。针对所有出生于1926年至1949年的瑞典男性同性双胞胎对。 [原文中“male-female”有误,应为“male-male”]

Multivariate genetic analysis of the causes of temperance board registrations. In all Swedish male-male [correction of male-female] twin pairs born 1926-1949.

作者信息

Kendler K S, Karkowski L M, Prescott C A, Neale M C, Pedersen N L

机构信息

Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA.

出版信息

Br J Psychiatry. 1998 Mar;172:268-72. doi: 10.1192/bjp.172.3.268.

Abstract

BACKGROUND

The Temperance Boards in Sweden registered individuals for three reasons: public drunkenness, driving under the influence of alcohol and committing a crime in connection with alcohol. We wanted to ascertain whether these three forms of alcohol-related problems result from similar or different genetic and environmental risk factors.

METHOD

We conducted a trivariate twin analysis of these three causes of registration in all male-male [corrected] twin pairs of known zygosity born in Sweden, 1926-1949 (n = 5177 twin pairs).

RESULTS

Prevalences of registration for public drunkenness, drink-driving and alcohol-related crime were, respectively, 9.0, 3.6 and 4.0%. The best-fitting model had one general genetic and one general familial-environmental factor with specific genetic risk factors for drink-driving and specific familial-environmental risk factors for alcohol-related crime.

CONCLUSIONS

The three causes for alcohol registration in Sweden largely reflect the same genetic and environmental risk factors. Estimated heritabilities were similar for the three forms of registration. However, specific genetic risk factors exist for drink-driving and specific familial-environmental risk factors for alcohol-related crime. Genetic factors are somewhat less important and familial-environmental factors more important for public drunkenness than for drink-driving and alcohol related crime.

摘要

背景

瑞典的禁酒委员会对个人进行登记有三个原因:公众醉酒、酒后驾车以及与酒精相关的犯罪。我们想要确定这三种与酒精相关的问题形式是由相似还是不同的遗传和环境风险因素导致的。

方法

我们对1926年至1949年在瑞典出生的所有已知合子性的男性-男性[校正后]双胞胎对中这三种登记原因进行了三变量双胞胎分析(n = 5177对双胞胎)。

结果

公众醉酒、酒后驾车和与酒精相关犯罪的登记患病率分别为9.0%、3.6%和4.0%。拟合度最佳的模型有一个一般遗传因素和一个一般家庭环境因素,以及酒后驾车的特定遗传风险因素和与酒精相关犯罪的特定家庭环境风险因素。

结论

瑞典酒精登记的三个原因在很大程度上反映了相同的遗传和环境风险因素。三种登记形式的估计遗传率相似。然而,酒后驾车存在特定的遗传风险因素,与酒精相关犯罪存在特定的家庭环境风险因素。与酒后驾车和与酒精相关犯罪相比,遗传因素对公众醉酒的重要性稍低,家庭环境因素对公众醉酒的重要性更高。

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