Henriksen O
Acta Physiol Scand. 1976 Jul;97(3):377-84. doi: 10.1111/j.1748-1716.1976.tb10277.x.
The effect of chronic sympathetic denervation upon the vasoconstrictor response to an increase of vascular transmural pressure in human subcutaneous adipose tissue was investigated in 6 patients suffering from manual hyperhidrosis. Changes in transmural pressure were obtained either by postural changes of a forearm or by venous stasis of 30 mmHg. Blood flow was measured in the distal part of the forearm or crus by means of the local 133Xenon washout technique. 2 patients were studied before and after sympathectomy. When the area under study was lowered about 40 cm below the jugular notch, blood flow decreased about 50% preoperatively, about 30% 24 h after the operation, but remained constant 4 days after or later. Similar results were obtained during venous stasis. Hence about 4 days after sympathectomy, the vasoconstrictor response to an increase in vascular transmural pressure was abolished. In 3 chronically sympathectomized patients blood flow remained constant in the denervated limb, but decreased significantly in the control limb. In another patient studied 580 days after surgery blood flow remained constant during lowering of the denervated forearm as well as during venous stasis. These findings might indicate that the vasoconstrictor response to an increase in vascular transmural pressure in human subcutaneous adipose tissue is due to a local nervous mechanism involving symphathetic adrenergic nerves, but a myogenic mechanism cannot be definitively excluded.
对6例患有手部多汗症的患者研究了慢性交感神经去神经支配对人体皮下脂肪组织血管收缩反应（因血管跨壁压升高所致）的影响。通过前臂姿势改变或30 mmHg的静脉淤滞来实现跨壁压的变化。采用局部133氙洗脱技术在前臂或小腿远端测量血流量。对2例患者在交感神经切除术前和术后进行了研究。当研究区域位于颈静脉切迹下方约40 cm处时，术前血流量下降约50%，术后24小时下降约30%，但在术后4天及以后保持稳定。在静脉淤滞期间也获得了类似结果。因此，交感神经切除术后约4天，对血管跨壁压升高的血管收缩反应消失。在3例长期交感神经切除的患者中，去神经支配肢体的血流量保持稳定，但对照肢体的血流量显著下降。在另一例术后580天进行研究的患者中，在去神经支配的前臂下降过程以及静脉淤滞期间，血流量均保持稳定。这些发现可能表明，人体皮下脂肪组织对血管跨壁压升高的血管收缩反应是由于涉及交感肾上腺素能神经的局部神经机制，但不能完全排除肌源性机制。
