Bang H O, Dyerberg J, Hjøorne N
Acta Med Scand. 1976;200(1-2):69-73. doi: 10.1111/j.0954-6820.1976.tb08198.x.
Food specimens have been collected, by means of the double-portion technique, from Greenland Eskimo hunters and their wives, in all seven persons, on seven consecutive days. Their food was found to contain more protein and less carbohydrates than average Danish food and an almost equal amount of fat. Compared with Danish food, the fatty acid pattern of the consumed lipids--essentially of mammalian marine origin--showed a higher content of long chain polyunsaturated fatty acids (especially C20:5) and lower contents of linoleic and linolenic acids. However, the sum of the polyunsaturated fatty acids was smaller than in Danish food. Using Keys' formula, describing the serum cholesterol level as a function of the nutritional fatty acids, the essentially lower serum choelsterol level found in Greenland Eskimos was not explained by our findings. It is suggested instead to be a special metabolic effect of the long chain polyunsaturated fatty acids from marine mammals. There might be a similar effect on the plasma triglyceride and very low density lipoprotein concentrations, explaining the much lower plasma concentrations of these components in Eskimos than in Western populations. Our findings might have an essential bearing on the difference in morbidity from coronary atherosclerotic disease between these populations.
采用双份技术,连续七天从格陵兰爱斯基摩猎人及其妻子共七人身上采集食物样本。发现他们的食物比丹麦普通食物含有更多的蛋白质和更少的碳水化合物,脂肪含量几乎相同。与丹麦食物相比,所摄入脂质(主要源自海洋哺乳动物)的脂肪酸模式显示长链多不饱和脂肪酸(尤其是C20:5)含量较高,而亚油酸和亚麻酸含量较低。然而,多不饱和脂肪酸的总量比丹麦食物中的要少。使用将血清胆固醇水平描述为营养脂肪酸函数的凯斯公式,我们的研究结果无法解释格陵兰爱斯基摩人血清胆固醇水平明显较低的现象。相反,这被认为是海洋哺乳动物来源的长链多不饱和脂肪酸的一种特殊代谢效应。这可能对血浆甘油三酯和极低密度脂蛋白浓度有类似影响,解释了爱斯基摩人这些成分的血浆浓度远低于西方人群的原因。我们的研究结果可能对这些人群中冠状动脉粥样硬化疾病发病率的差异具有重要影响。