Saito K, Yoshioka H, Cutler R G
Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Biosci Biotechnol Biochem. 1998 Apr;62(4):792-4. doi: 10.1271/bbb.62.792.
To characterize the pharmacological effects of N-tert-butyl-alpha-phenylnitrone (PBN) on life span, we administered PBN in drinking water to 24.5-month-old mice, and the survivors were counted. Their water consumption and body weights were measured as biological markers. PBN-treated animals as compared with control animals had prolonged mean and maximum life spans. Their water consumption decreased but no significant change was found in their body weights, indicating that the metabolism was improved. Results showed that PBN indeed affects physiological functions and extends life span. We propose that nitric oxide release from PBN may be involved in altering the aging process.
为了表征N-叔丁基-α-苯基硝酮（PBN）对寿命的药理作用，我们将PBN添加到饮用水中喂给24.5月龄的小鼠，并统计存活小鼠数量。测量它们的饮水量和体重作为生物学指标。与对照动物相比，接受PBN处理的动物平均寿命和最长寿命均延长。它们的饮水量减少，但体重未发现显著变化，这表明新陈代谢得到改善。结果表明，PBN确实会影响生理功能并延长寿命。我们认为，PBN释放的一氧化氮可能参与改变衰老过程。
