Sugumaran D S
Department of Medicine, Schieffelin Leprosy & Research Training Centre, Tamil Nadu, South India.
Int J Lepr Other Mycobact Dis. 1998 Mar;66(1):10-5.
The adverse effects of corticosteroid therapy while treating 830 patients suffering from leprosy reaction (type 1 = 581; type 2 = 249) are presented. Some of the adverse effects were cosmetically distressing, while others were disabling. Patients suffering from type 2 reaction--because of the tendency of the reaction to recur over a long time--needed steroids for a longer duration; hence, adverse effects were more frequent. Measures to counter some of the adverse effects are suggested and the need to identify drugs with potentially less adverse effects is emphasized.
本文介绍了对830例麻风反应患者（1型581例；2型249例）进行皮质类固醇治疗的不良反应。有些不良反应在外观上令人苦恼，而有些则会导致残疾。2型反应患者由于反应有长期复发的倾向，需要使用类固醇的时间更长；因此，不良反应更频繁。文中提出了应对一些不良反应的措施，并强调了识别潜在不良反应较少的药物的必要性。
