Nygaard B, Nygaard T, Jensen L I, Court-Payen M, Søe-Jensen P, Nielsen K G, Fugl M, Hansen J M
Department of Endocrinology, Herlev Hospital, University of Copenhagen, Denmark.
Acad Radiol. 1998 Jun;5(6):409-14. doi: 10.1016/s1076-6332(98)80026-3.
The authors attempted to determine whether the use of nonionic contrast media causes uptake of iodine by the thyroid to be blocked and whether use of these agents could cause iodine-induced hyperthyroidism.
Twenty-eight persons, including 22 with thyroid disease, were included in the study. Subjects underwent computed tomography (CT) of the thyroid after injection of 100 mL of iohexol. Thyroid function variables were measured before CT scanning and 1 week and 1 month later. In 16 subjects, uptake of iodine-131 by the thyroid was measured before and 1 week after CT.
I-131 uptake was reduced to 53.4% at 1 week after the injection of iohexol but became normal within a few weeks (followed up in one patient). An accelerated escape of I-131 from the thyroid was seen during the 1st days after the iohexol administration. Eight of 22 patients with an underlying thyroid disease had a temporary change in thyroid function. In four patients, the serum thyrotropin level was increased 1 week after the iohexol administration. In four other patients, temporary hyperthyroidism developed during the following months.
Iohexol can be used in patients with an underlying thyroid disease, but close monitoring in the following months is necessary.
作者试图确定使用非离子型造影剂是否会阻止甲状腺摄取碘，以及使用这些药物是否会导致碘致甲状腺功能亢进。
28人纳入本研究，其中22人患有甲状腺疾病。受试者在注射100 mL碘海醇后接受甲状腺计算机断层扫描（CT）。在CT扫描前、扫描后1周和1个月测量甲状腺功能变量。16名受试者在CT扫描前和扫描后1周测量甲状腺对碘-131的摄取。
注射碘海醇后1周，碘-131摄取降至53.4%，但在几周内恢复正常（对1例患者进行了随访）。在碘海醇给药后的头几天，观察到碘-131从甲状腺加速排出。22例患有基础甲状腺疾病的患者中有8例甲状腺功能出现暂时变化。4例患者在碘海醇给药后1周血清促甲状腺素水平升高。另外4例患者在随后几个月出现暂时性甲状腺功能亢进。
碘海醇可用于患有基础甲状腺疾病的患者，但在随后几个月需要密切监测。
