Kuwabara H, Uda H, Miyabe K, Saito K, Shibanushi T
Department of Pathology, Kagawa Medical University, Japan.
Ultrastruct Pathol. 1998 Mar-Apr;22(2):153-60. doi: 10.3109/01913129809032271.
Predominant benign plasmacytoid myoepithelial cells in pleomorphic adenoma and malignant plasmacytoid myoepithelioma cells were investigated morphologically. The cells of both tumors were plasmacytoid in appearance and sheet-like. Immunohistochemically, they were positive for keratin, vimentin, and S-100 protein, and negative for alpha-smooth muscle actin. In the malignant cells, large nuclei with irregular nuclear membranes and distinct nucleoi and occasional intranuclear inclusions and nuclear grooves were seen. Ultrastructural findings showed that the benign cells were richer in intermediate filaments and had fewer mitochondria. The intranuclear inclusions and nuclear grooves of the malignant cells were caused by invagination of the irregular nuclear membranes. Taken in their entirety, the above light microscopical nuclear findings may be useful as an adjunct for distinguishing malignant from benign plasmacytoid neoplastic myoepithelial cells of the salivary gland.
对多形性腺瘤中占主导地位的良性浆细胞样肌上皮细胞和恶性浆细胞样肌上皮瘤细胞进行了形态学研究。两种肿瘤的细胞外观均呈浆细胞样且呈片状。免疫组织化学显示，它们对角蛋白、波形蛋白和S-100蛋白呈阳性，对α-平滑肌肌动蛋白呈阴性。在恶性细胞中，可见核大、核膜不规则、核仁明显，偶尔可见核内包涵体和核沟。超微结构研究结果表明，良性细胞中中间丝更丰富，线粒体较少。恶性细胞的核内包涵体和核沟是由不规则核膜内陷引起的。综上所述，上述光镜下的核特征可能有助于辅助鉴别涎腺良性与恶性浆细胞样肿瘤性肌上皮细胞。
