Cuadra Zelaya Florence, Quezada Rivera Daniel, Tapia Vazquez José Luis, Paez Valencia Carlos, Gaitán Cepeda Luis Alberto
Oral Pathology Laboratory, Postgraduate and Research Division, Dental School, National Autonomous University of Mexico, México city, México.
Med Oral Patol Oral Cir Bucal. 2007 Dec 1;12(8):E552-5.
Myoepithelioma is a benign neoplasm of salivary glands, represents 1.5 % of all salivary glands neoplasm. The plasmacytoid myoepithelioma from palate salivary glands is considered as a rare entity, at date it has been reported 14 cases. It is present one case of plasmacytoid myoepithelioma of palate.
A Hispanic female of 28 years old presented a not-ulcerate, painless ovoid swelling at left side of hard palate with a one year and a half of evolution. An excisional biopsy was done. The sample was fixed at 10% buffer formalin, embedded in paraffin, cuts at 5 micron and stained with H-E. Microscopically, the lesion was composed by myoepithelial neoplastic cells characterized by a round ovoid silhouette, an eccentric nuclei of dense chromatin and eosinophilic cytoplasm. In some myoepithelial neoplastic cells were identifies intranuclear cytoplasmatic inclusions. The lesion was analysed with immunohistochemical technique using the follow antibodies: vimentin, citokeratin AE1/AE3, S100 protein and actin muscle specific. We observe positive immunoreactivity against vimentin, citokeratin, S100 protein and actin muscle specific. A diagnosis of plasmacytoid myoephitelioma of palate salivary glands was done. Our findings supports the suggestion about plasmacytoid myoepithelioma is an independent entity. The histological diagnostic parameters of plasmacytoid myoepithelioma versus pleomorphic adenoma are discussed.
肌上皮瘤是涎腺的一种良性肿瘤，占所有涎腺肿瘤的1.5%。腭部涎腺的浆细胞样肌上皮瘤被认为是一种罕见的实体，迄今为止已报道14例。本文报道1例腭部浆细胞样肌上皮瘤。
一名28岁的西班牙裔女性，硬腭左侧出现一个无溃疡、无痛的卵圆形肿物，病程为一年半。进行了切除活检。样本用10%缓冲福尔马林固定，石蜡包埋，切成5微米厚的切片，并用苏木精-伊红染色。显微镜下，病变由肌上皮肿瘤细胞组成，其特征为圆形或卵圆形轮廓、核偏位、染色质致密且胞质嗜酸性。在一些肌上皮肿瘤细胞中发现了核内胞质包涵体。使用以下抗体通过免疫组织化学技术对病变进行分析：波形蛋白、细胞角蛋白AE1/AE3、S100蛋白和肌动蛋白。我们观察到对波形蛋白、细胞角蛋白、S100蛋白和肌动蛋白呈阳性免疫反应。诊断为腭部涎腺浆细胞样肌上皮瘤。我们的发现支持浆细胞样肌上皮瘤是一个独立实体的观点。本文讨论了浆细胞样肌上皮瘤与多形性腺瘤的组织学诊断参数。
