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[皮肤浅表黑色素瘤的外科治疗]

[Surgical treatment of superficial melanoma of the skin].

作者信息

Demidov L V, Barchuk A S

机构信息

N.N. Blokhin Center for Cancer Research, Russian Academy of Medical Sciences, Moscow.

出版信息

Vopr Onkol. 1998;44(2):149-54.

PMID:9615816
Abstract

The 12-year end-results of standard "wide" and sparing "narrow" excision of superficial skin melanoma are compared. The results were contributed by a joint study of the WHO Collaborating Centers for Evaluation of Methods of Diagnosis and Treatment of Melanoma headed by Dr. U. Veronesi and Dr. N. Cascinelli and 23 other centers in different countries (the Blokhin and Petrov Centers in Russia). The investigation comprised 612 patients. After randomization, "narrow" excision of primary tumor with 1 cm-wide margins was performed in 305 patients. In the remaining 307 patients, "wide" excision left margins within 3 cm. Tumor was identified as superficial on the basis of thickness (Breslow), the threshold being 2 mm-thick invasion. This same prognostic indicator was used in both groups. Another one was 12 year-long recurrence-free survival. The sparing excision of primary cutaneous melanoma with a thickness under 2 cm proved effective.

摘要

对标准“广泛”和保留性“狭窄”切除浅表皮肤黑色素瘤的12年最终结果进行了比较。这些结果来自由U. 韦罗内西博士和N. 卡斯奇内利博士领导的世界卫生组织黑色素瘤诊断和治疗方法评估合作中心与其他23个不同国家的中心(俄罗斯的布洛欣中心和彼得罗夫中心)的联合研究。该调查包括612名患者。随机分组后,305名患者对原发性肿瘤进行了边缘为1厘米宽的“狭窄”切除。其余307名患者中,“广泛”切除的边缘在3厘米以内。根据厚度(布雷斯洛)将肿瘤确定为浅表性,阈值为2毫米厚的浸润。两组均使用相同的预后指标。另一个指标是12年无复发生存率。事实证明,对厚度小于2厘米的原发性皮肤黑色素瘤进行保留性切除是有效的。

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