Clement P B, Scully R E
Am J Clin Pathol. 1976 Sep;66(3):512-25. doi: 10.1093/ajcp/66.3.512.
Uterine tumors with histologic resemblances to ovarian sex-cord tumors were encountered in 14 women in the fourth to sixth decades of life, most of whom had abnormal vaginal bleeding and enlarged uteri suggesting leiomyomas. The tumors in six cases (Group I) were identical to one or another form of well-recognized endometrial stromal tumor except for focal epithelial-like differentiation resembling that seen in sex-cord tumors. These tumors were mostly poorly circumscribed large mural masses. The focal sex-cord-like differentiation was manifested by cords, trabeculae, nests and tubules of epithelial-like cells; eosinophilic bodies resembling Call-Exner bodies were seen in one case. Five of the six patients with tumors of this type have been followed for postoperative intervals of 22 months to 15 years, and pelvic recurrences have developed in three. The tumors in eight cases (Group II) differed from those in Group I by having a predominant or exclusive pattern reminiscent of an ovarian sex-cord tumor. These tumors, most of which were single, well-circumscribed, yellow to tan, mural masses 4 to 10 cm in diameter, appeared benign, with no recurrence during postoperative periods of four months to seven years. The relations of the two groups of tumors to one another and to previously described similar tumors. including so-called granulosa-cell tumors and "plexiform tumors" of the uterus, are discussed, and an origin from endometrial stromal cells is postulated.
在14名年龄为40至60岁的女性中发现了组织学上与卵巢性索肿瘤相似的子宫肿瘤，她们中的大多数有异常阴道出血和子宫增大，提示为平滑肌瘤。6例肿瘤（第一组）除了有类似于性索肿瘤中所见的局灶性上皮样分化外，与一种或另一种公认的子宫内膜间质肿瘤相同。这些肿瘤大多边界不清，为较大的壁间肿块。局灶性性索样分化表现为上皮样细胞的条索、小梁、巢状和管状结构；1例可见类似于Call-Exner小体的嗜酸性小体。6例患有此类肿瘤的患者中有5例术后随访了22个月至15年，其中3例出现盆腔复发。8例肿瘤（第二组）与第一组不同，其主要或唯一的模式让人联想到卵巢性索肿瘤。这些肿瘤大多为单个，边界清楚，直径4至10厘米，呈黄色至棕褐色，为壁间肿块，看起来为良性，在术后4个月至7年期间无复发。讨论了两组肿瘤之间以及它们与先前描述的类似肿瘤（包括所谓的子宫颗粒细胞瘤和“丛状肿瘤”）的关系，并推测其起源于子宫内膜间质细胞。
