Davies A N, Daniels C, Pugh R, Sharma K
St Christopher's Hospice, London, UK.
Palliat Med. 1998 Mar;12(2):105-11. doi: 10.1191/026921698670435903.
This was a crossover study comparing a mucin-based artificial saliva (Saliva Orthana) and pilocarpine hydrochloride (Salagen) in the management of xerostomia in patients with advanced cancer. The pilocarpine was found to be more effective than the artificial saliva in terms of mean change in visual analogue scale scores for xerostomia (P = 0.003). Furthermore, more patients reported that it had helped their xerostomia, and more patients wanted to continue with it after the study. However, the pilocarpine was found to be associated with more side-effects than the artificial saliva (P < 0.001). These side-effects were usually reported as being mild. Of the patients who used both treatments, 50% preferred the artificial saliva, and 50% preferred the pilocarpine. The commonest reason for preferring the artificial saliva was the fact that it was a spray, rather than a tablet.
这是一项交叉研究，比较了一种基于粘蛋白的人工唾液（Saliva Orthana）和盐酸毛果芸香碱（Salagen）对晚期癌症患者口干症的治疗效果。就口干症视觉模拟量表评分的平均变化而言，发现毛果芸香碱比人工唾液更有效（P = 0.003）。此外，更多患者报告称它对缓解口干症有帮助，并且更多患者在研究结束后希望继续使用它。然而，发现毛果芸香碱比人工唾液有更多的副作用（P < 0.001）。这些副作用通常报告为轻度。在同时使用两种治疗方法的患者中，50% 更喜欢人工唾液，50% 更喜欢毛果芸香碱。更喜欢人工唾液的最常见原因是它是喷雾剂，而不是片剂。
