免疫缺陷、黄色瘤和阻塞性肝病。

Immunodeficiency, xanthomas and obstructive liver disease.

作者信息

Isenberg J N, Hanson R F, Williams G C, Zavoral J, Page A R, Sharp H L

出版信息

Am J Med. 1976 Sep;61(3):393-400. doi: 10.1016/0002-9343(76)90377-6.

Abstract

Chronic obstructive liver disease and secondary hyperlipidemia developed in an immunodeficient boy. Sequential addition of cholestyramine and phenobarbital to his medical regimen, following an initial response to bile drainage, resulted in the disappearance of xanthomas and pruritus, and the restoration of normal serum concentrations of lipids and bile acids. This improvement may result from shifting the bile acid pool from the peripheral blood compartment to the enterohepatic circulation.

摘要

一名免疫缺陷男孩患了慢性阻塞性肝病和继发性高脂血症。在对胆汁引流初步产生反应后，其治疗方案中先后添加了消胆胺和苯巴比妥，结果黄瘤和瘙痒消失，血脂和胆汁酸的血清浓度恢复正常。这种改善可能是由于胆汁酸池从外周血腔转移至肠肝循环所致。