人体内胆酸和鹅去氧胆酸的肠肝循环率。
Enterohepatic circulation rates of cholic acid and chenodeoxycholic acid in man.
作者信息
Einarsson K A, Gundy S M, Hardison W G
出版信息
Gut. 1979 Dec;20(12):1078-82. doi: 10.1136/gut.20.12.1078.
The rate of enterohepatic cycling of cholic acid and chenodeoxycholic acid was determined in five male subjects. Pool sizes were measured by isotope dilution technique after intraduodenal administration of 14C-labelled cholic and chenodeoxycholic acid. The hourly hepatic secretion rate of bile acids was determined by an intestinal perfusion technique. From these data the cycling frequency was calculated. Chenodeoxycholic acid circulated on an average 1.34 (range, 1.13--1.57) times faster than cholic acid, probably because chenodeoxycholic acid to a larger extent than cholic acid is absorbed from the proximal small intestine and thus partly bypasses the hepaticoileal circuit. This difference in cycling rate may have methodological as well as physiological implications.
在五名男性受试者中测定了胆酸和鹅去氧胆酸的肠肝循环速率。在十二指肠内给予14C标记的胆酸和鹅去氧胆酸后，通过同位素稀释技术测量池大小。通过肠灌注技术测定胆汁酸的每小时肝脏分泌率。根据这些数据计算循环频率。鹅去氧胆酸的循环平均比胆酸快1.34倍（范围为1.13 - 1.57），这可能是因为鹅去氧胆酸比胆酸在更大程度上从小肠近端吸收，从而部分绕过肝-回肠循环。这种循环速率的差异可能具有方法学以及生理学意义。
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