Randall M D, Kendall D A
School of Biomedical Sciences, University of Nottingham Medical School, Queen's Medical Centre, UK.
Eur J Pharmacol. 1998 Apr 3;346(1):51-3. doi: 10.1016/s0014-2999(98)00003-x.
We have recently proposed that an endocannabinoid, of which anandamide is prototypic, may be an endothelium-derived hyperpolarizing factor (EDHF). In the present study, both anandamide-induced and EDHF-mediated relaxations were insensitive to either charybdotoxin (100 nM) or apamin (500 nM) alone, but were inhibited by these agents in combination. These results point to EDHF and anandamide acting at a common site to cause vasorelaxation via K+ channel activation, and support our proposal that an endocannabinoid is an EDHF.
我们最近提出，以内源性大麻素花生四烯乙醇胺为原型的一种内源性大麻素，可能是一种内皮衍生超极化因子（EDHF）。在本研究中，花生四烯乙醇胺诱导的舒张和EDHF介导的舒张对单独使用的蝎毒素（100 nM）或蜂毒明肽（500 nM）均不敏感，但联合使用这些药物时会受到抑制。这些结果表明，EDHF和花生四烯乙醇胺通过激活钾通道在共同位点发挥作用导致血管舒张，支持了我们关于内源性大麻素是一种EDHF的提议。
