Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, P. R. China.
Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing, P. R. China.
Cell Death Dis. 2019 Jun 24;10(7):497. doi: 10.1038/s41419-019-1708-9.
The transient receptor potential ion-channel superfamily consists of nonselective cation channels located mostly on the plasma membranes of numerous animal cell types, which are closely related to sensory information transmission (e.g., vision, pain, and temperature perception), as well as regulation of intracellular Ca balance and physiological activities of growth and development. Transient receptor potential ion channel subfamily V (TRPV) is one of the largest and most diverse subfamilies, including TRPV1-TRPV6 involved in the regulation of a variety of cellular functions. TRPV4 can be activated by various physical and chemical stimuli, such as heat, mechanical force, and phorbol ester derivatives participating in the maintenance of normal cellular functions. In recent years, the roles of TRPV4 in cell proliferation, differentiation, apoptosis, and migration have been extensively studied. Its abnormal expression has also been closely related to the onset and progression of multiple tumors, so TRPV4 may be a target for cancer diagnosis and treatment. In this review, we focused on the latest studies concerning the role of TRPV4 in tumorigenesis and the therapeutic potential. As evidenced by the effects on cancerogenesis, TRPV4 is a potential target for anticancer therapy.
瞬时受体电位离子通道超家族由位于许多动物细胞类型的质膜上的非选择性阳离子通道组成，与感觉信息传递（例如视觉、疼痛和温度感知）以及细胞内 Ca 平衡的调节和生长发育的生理活动密切相关。瞬时受体电位离子通道亚家族 V（TRPV）是最大和最多样化的亚家族之一，包括 TRPV1-TRPV6，参与调节各种细胞功能。TRPV4 可以被各种物理和化学刺激激活，如热、机械力和佛波酯衍生物，参与维持正常细胞功能。近年来，TRPV4 在细胞增殖、分化、凋亡和迁移中的作用已被广泛研究。其异常表达也与多种肿瘤的发生和发展密切相关，因此 TRPV4 可能是癌症诊断和治疗的靶点。在这篇综述中，我们重点介绍了 TRPV4 在肿瘤发生中的作用及其治疗潜力的最新研究。正如对癌症发生的影响所证明的那样，TRPV4 是一种潜在的抗癌治疗靶点。
