Francesconi R, Mager M
Am J Physiol. 1976 Jul;231(1):148-52. doi: 10.1152/ajplegacy.1976.231.1.148.
Exogenously administered monoamines may elicit variable thermoregulatory responses dependent on dosage, species, site of administration, ambient temperature, etc. In an attempt to reconcile several inconsistencies, we have undertaken a series of studies related to monoaminergic control of temperature regulation. Thus, intraventricular administration of serotonin (2.64-26.4 mug) and norepinephrine (3.3-32.8 mug) in rats evoked acute (15-60 min) dose-dependent hypothermic responses (delta Tre = 2 degrees C) that were gradually superseded by significant, more persistent hyperthermia (delta Tre = 1 degreee C). Administration of chlorimipramine or imipramine (total dose 40 mug), even in monoamine-depleted animals, caused long-lasting hyperthermic responses, presumably by the prevention of reuptake of serotonin and norepinephrine at nerve terminals involved in thermoregulation. Pretreatment with the serotonin inhibitor cyproheptadine (4o mug) attenuated the hyperthermia achieved by central administration of chlorimipramine alone. We conclude that both monoamines can act as thermogenic agents under the conditions of these experiments.
外源性给予单胺类物质可能会引发取决于剂量、物种、给药部位、环境温度等因素的可变体温调节反应。为了协调一些不一致的情况，我们进行了一系列与单胺能对体温调节的控制相关的研究。因此，在大鼠脑室内给予血清素（2.64 - 26.4微克）和去甲肾上腺素（3.3 - 32.8微克）会引发急性（15 - 60分钟）剂量依赖性体温过低反应（ΔTre = 2摄氏度），随后这种反应会逐渐被显著且更持久的体温过高反应（ΔTre = 1摄氏度）所取代。给予氯米帕明或丙咪嗪（总剂量40微克），即使是在单胺耗竭的动物中，也会引起持久的体温过高反应，推测这是通过阻止参与体温调节的神经末梢处血清素和去甲肾上腺素的再摄取来实现的。用血清素抑制剂赛庚啶（40微克）预处理可减弱单独通过脑室内给予氯米帕明所达到的体温过高反应。我们得出结论，在这些实验条件下，两种单胺都可作为产热剂。
