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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

J Physiol. 1978 Nov;284:147-54. doi: 10.1113/jphysiol.1978.sp012532.

The effects of two inhibitors of uptake pump in serotonergic neurons, Lilly 110140 and chlorimipramine, on the thermoregulatory responses of unanaesthetized rats to different ambient temperatures (Ta) of 8, 22 and 30 degrees C were assessed. 2. Intraperitoneal administration of either Lilly 110140 or chlorimipramine produced dose-dependent hypothermia at 8 and 22 degrees C Ta. At 8 degrees C Ta the hypothermia was due to a decrease in metabolic heat production. At 22 degrees C Ta, the hypothermia was brought about by both a decrease in metabolic heat production and an increase in cutaneous temperature of the tail and the footsole. 3. However, at 30 degrees C Ta, there were no changes in rectal temperature in response to either Lilly 110140 or chlorimipramine application. 4. The data suggest that an increase in serotonergic receptor activity or in functional serotonin in brain decreases heat production and/or increases heat loss and leads to hypothermia in rats.

评估了血清素能神经元摄取泵的两种抑制剂——礼来110140和氯米帕明，对未麻醉大鼠在8、22和30摄氏度不同环境温度（Ta）下体温调节反应的影响。2. 腹腔注射礼来110140或氯米帕明在8和22摄氏度Ta时产生剂量依赖性体温过低。在8摄氏度Ta时，体温过低是由于代谢产热减少。在22摄氏度Ta时，体温过低是由代谢产热减少以及尾巴和足底皮肤温度升高共同导致的。3. 然而，在30摄氏度Ta时，应用礼来110140或氯米帕明后直肠温度没有变化。4. 数据表明，大脑中血清素能受体活性增加或功能性血清素增加会减少产热和/或增加散热，并导致大鼠体温过低。

J Physiol. 1978 Nov;284:147-54. doi: 10.1113/jphysiol.1978.sp012532.

The effects of two inhibitors of uptake pump in serotonergic neurons, Lilly 110140 and chlorimipramine, on the thermoregulatory responses of unanaesthetized rats to different ambient temperatures (Ta) of 8, 22 and 30 degrees C were assessed. 2. Intraperitoneal administration of either Lilly 110140 or chlorimipramine produced dose-dependent hypothermia at 8 and 22 degrees C Ta. At 8 degrees C Ta the hypothermia was due to a decrease in metabolic heat production. At 22 degrees C Ta, the hypothermia was brought about by both a decrease in metabolic heat production and an increase in cutaneous temperature of the tail and the footsole. 3. However, at 30 degrees C Ta, there were no changes in rectal temperature in response to either Lilly 110140 or chlorimipramine application. 4. The data suggest that an increase in serotonergic receptor activity or in functional serotonin in brain decreases heat production and/or increases heat loss and leads to hypothermia in rats.

评估了血清素能神经元摄取泵的两种抑制剂——礼来110140和氯米帕明，对未麻醉大鼠在8、22和30摄氏度不同环境温度（Ta）下体温调节反应的影响。2. 腹腔注射礼来110140或氯米帕明在8和22摄氏度Ta时产生剂量依赖性体温过低。在8摄氏度Ta时，体温过低是由于代谢产热减少。在22摄氏度Ta时，体温过低是由代谢产热减少以及尾巴和足底皮肤温度升高共同导致的。3. 然而，在30摄氏度Ta时，应用礼来110140或氯米帕明后直肠温度没有变化。4. 数据表明，大脑中血清素能受体活性增加或功能性血清素增加会减少产热和/或增加散热，并导致大鼠体温过低。