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Nitric oxide (NO) production in C6 glioma cells was directly monitored in real time by electrochemical detection with a NO-specific biosensor. 2. We present here the first direct evidence that noradrenaline elicits long-lasting NO production in C6 cells pretreated with lipopolysaccharide and interferon-gamma, an effect blocked by NG-monomethyl-L-arginine, a NO synthase inhibitor. 3. This direct electrochemical measurement of glia-derived NO should facilitate our understanding of the kinetics of glial signaling in glia-glia and glia-neuron networks in the brain.

通过使用一氧化氮特异性生物传感器进行电化学检测，实时直接监测C6胶质瘤细胞中一氧化氮（NO）的产生。2. 我们在此首次提供直接证据，即去甲肾上腺素在经脂多糖和干扰素-γ预处理的C6细胞中引发持久的NO产生，该效应被一氧化氮合酶抑制剂NG-单甲基-L-精氨酸阻断。3. 这种对神经胶质细胞衍生的NO的直接电化学测量应有助于我们理解大脑中神经胶质细胞-神经胶质细胞和神经胶质细胞-神经元网络中神经胶质信号传导的动力学。

Nitric oxide (NO) production in C6 glioma cells was directly monitored in real time by electrochemical detection with a NO-specific biosensor. 2. We present here the first direct evidence that noradrenaline elicits long-lasting NO production in C6 cells pretreated with lipopolysaccharide and interferon-gamma, an effect blocked by NG-monomethyl-L-arginine, a NO synthase inhibitor. 3. This direct electrochemical measurement of glia-derived NO should facilitate our understanding of the kinetics of glial signaling in glia-glia and glia-neuron networks in the brain.

通过使用一氧化氮特异性生物传感器进行电化学检测，实时直接监测C6胶质瘤细胞中一氧化氮（NO）的产生。2. 我们在此首次提供直接证据，即去甲肾上腺素在经脂多糖和干扰素-γ预处理的C6细胞中引发持久的NO产生，该效应被一氧化氮合酶抑制剂NG-单甲基-L-精氨酸阻断。3. 这种对神经胶质细胞衍生的NO的直接电化学测量应有助于我们理解大脑中神经胶质细胞-神经胶质细胞和神经胶质细胞-神经元网络中神经胶质信号传导的动力学。

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