Davison R M
Department of Medicine, University College London, School of Medicine, Middlesex Hospital, London, UK.
Curr Opin Obstet Gynecol. 1998 Jun;10(3):193-8. doi: 10.1097/00001703-199806000-00003.
The aetiology of the polycystic ovarian syndrome together with new advances in the molecular genetics and possible candidate genes for the inheritance of the syndrome is discussed. The possible role of leptin in the obesity of polycystic ovarian syndrome is reviewed. Hyperinsulinaemia acts not only as the trigger for hyperandrogenaemia and infertility, but also by stimulating plasminogen activator inhibitor type 1; hyperinsulinaemia may also promote atherogenesis in polycystic ovarian syndrome. The long-term effects of the metabolic derangements accompanying hyperinsulinaemia are reviewed. Special emphasis is placed on the use of novel insulin sensitizers such as troglitazone which promise new treatment opportunities in polycystic ovarian syndrome for both fertility and long-term disease prevention.
本文讨论了多囊卵巢综合征的病因，以及分子遗传学方面的新进展和该综合征遗传的可能候选基因。综述了瘦素在多囊卵巢综合征肥胖中的可能作用。高胰岛素血症不仅是高雄激素血症和不孕的触发因素，还通过刺激1型纤溶酶原激活物抑制剂发挥作用；高胰岛素血症也可能促进多囊卵巢综合征患者的动脉粥样硬化形成。本文综述了高胰岛素血症伴随的代谢紊乱的长期影响。特别强调了新型胰岛素增敏剂如曲格列酮的应用，其有望为多囊卵巢综合征的生育和长期疾病预防带来新的治疗机会。
