Alabovskiĭ V V, Vinokurov A A
Fiziol Zh (1994). 1994 Mar-Apr;40(2):92-6.
It is shown that reperfusion of the postischemic heart by low-calcium solution and standard media was accompanied by a massive release of myoglobine, contracture development without cardiac contractions. Addition of amiloride (35 mmol/1) 5 min before ischemia and during low-calcium reperfusion prevents the heart damage after reintroduction of the standard-calcium media. We consider that high susceptibility of the postischemic heart to calcium paradox can be explained by activation of Na/H exchange and a decrease in the sodium gradient during low-calcium reperfusion. These findings confirm the so-called "intracellular sodium" hypothesis of the calcium paradox.
