Lundeen G A, Shea K G, Sanderson C, Bachus K N, Bloebaum R D
Bone and Joint Research Lab, VA Medical Center, Salt Lake City, Utah 84148, USA.
J Biomed Mater Res. 1998 Summer;43(2):168-74. doi: 10.1002/(sici)1097-4636(199822)43:2<168::aid-jbm11>3.0.co;2-e.
Metal implants are being used with increasing frequency for the treatment of many diseases in the field of orthopedics, cardiology, cardiovascular surgery, and otolaryngology. Unfortunately, metals can be a source of submicron particles, which may have adverse effects on tissues. This article describes a technique that uses backscattered electron imaging and energy dispersive X-ray microanalysis, which have the capacity to perform both quantitative and qualitative analysis. The particles can be characterized by size, shape, amount, and composition. Although this technique can be used near the implant interface, it is particularly helpful in tissues a great distance from the implant site with a low concentration of metal debris. In addition, the sensitivity and specificity of this technique can be adjusted to the investigator's needs.
金属植入物在骨科、心脏病学、心血管外科和耳鼻喉科等领域治疗多种疾病中的使用频率越来越高。不幸的是，金属可能是亚微米颗粒的来源，这些颗粒可能对组织产生不利影响。本文描述了一种使用背散射电子成像和能量色散X射线微分析的技术，该技术能够进行定量和定性分析。这些颗粒可以通过大小、形状、数量和成分来表征。尽管该技术可用于植入物界面附近，但在距离植入部位很远且金属碎片浓度较低的组织中特别有用。此外，该技术的灵敏度和特异性可根据研究者的需求进行调整。
