Kammerer W S, Judge D M
Am J Trop Med Hyg. 1976 Sep;25(5):714-7. doi: 10.4269/ajtmh.1976.25.714.
We treated female Swiss Webster mice with heavy, long standing infections of Echinococcus granulosus with mebendazole, 50 mg/kg body weight daily for 10 days and bithionol, 70 mg/kg every other day for four doses. Necropsy performed 6 weeks after completion of therapy showed no gross or histologic differences between untreated controls and bithionol-treated mice or their cysts. Mebendazole-treated mice had a significant decrease in the total number of cysts (15 vs. 100), with many of those present being ruptured. Electron microscopy of intact, mebendazole-treated cysts revealed a marked increase in vacuolization and disarray of the distal cytoplasm, dilated and degenerating microtubules, increase in the size and number of lysosomes, a decrease in the number of normal appearing golgi, and increased density of mitochondria. Several mice died shortly after the termination of mebendazole therapy, all with ruptured cysts. Due to the large volume of the cysts, the presumed cause of death was acute volume overload, but toxic or anaphylactic reactions could not be excluded. We suggest that any proposed chemotherapy of humans with hydatid disease be done cautiously, with careful monitoring.
我们用甲苯达唑（每天50毫克/千克体重，持续10天）和硫双二氯酚（每两天70毫克/千克，共四剂）治疗患有严重、长期细粒棘球绦虫感染的雌性瑞士韦伯斯特小鼠。治疗结束6周后进行的尸检显示，未治疗的对照组与硫双二氯酚治疗的小鼠及其囊肿之间在大体或组织学上没有差异。甲苯达唑治疗的小鼠囊肿总数显著减少（15个对100个），且现存的许多囊肿已破裂。对完整的、经甲苯达唑治疗的囊肿进行电子显微镜检查发现，远端细胞质空泡化和排列紊乱明显增加，微管扩张和退化，溶酶体大小和数量增加，正常高尔基体数量减少，线粒体密度增加。几只小鼠在甲苯达唑治疗结束后不久死亡，均伴有囊肿破裂。由于囊肿体积大，推测死亡原因是急性容量超负荷，但不能排除毒性或过敏反应。我们建议，对任何拟议的人类包虫病化疗都应谨慎进行，并进行仔细监测。
