Teggi A, Lastilla M G, De Rosa F
Second Chair of Infectious Diseases, Università degli Studi di Roma La Sapienza, Italy.
Antimicrob Agents Chemother. 1993 Aug;37(8):1679-84. doi: 10.1128/AAC.37.8.1679.
We report our experience in the treatment with benzoimidazole carbamates (mebendazole and albendazole) of 337 patients affected by hydatid cysts with different localizations. The treated cysts showed degenerative modifications in 50.6% of the cases after mebendazole treatment and in about 80% after albendazole treatment. Relapses after therapy were observed in 30% of the cases; about 95% of the recurring cysts showed good susceptibility to a further cycle of therapy with benzoimidazole carbamates. Side effects observed with either drug were not severe and always reversible, consisting mainly of abdominal pains and increased levels of transaminases in serum. Among the factors that may influence the therapeutic results are the drug employed, the age of the cysts, the age of the patient, and the localization of the cysts and their morphological characteristics. Moreover, it can be hypothesized that each hydatid cyst has an intrinsic sensitivity to benzoimidazole carbamates.
我们报告了使用苯并咪唑氨基甲酸盐（甲苯咪唑和阿苯达唑）治疗337例不同部位包虫囊肿患者的经验。经甲苯咪唑治疗后，50.6%的病例中治疗的囊肿出现退行性改变，经阿苯达唑治疗后约80%出现这种改变。治疗后30%的病例出现复发；约95%的复发性囊肿对苯并咪唑氨基甲酸盐的进一步治疗周期表现出良好的敏感性。两种药物观察到的副作用均不严重且总是可逆的，主要包括腹痛和血清转氨酶水平升高。可能影响治疗结果的因素包括所用药物、囊肿的年龄、患者的年龄、囊肿的部位及其形态特征。此外，可以推测每个包虫囊肿对苯并咪唑氨基甲酸盐都有内在敏感性。
